B2C fulfillment is unit-level: each order is one or a few items packaged for an individual consumer. B2B fulfillment is pallet or case-level: orders go to retailers, distributors, or commercial buyers who receive in bulk.
The packaging requirements are different. B2C needs consumer-grade packaging, individual tracking numbers, and often retail-ready presentation. B2B needs case-pack integrity, pallet labels, and sometimes EDI-compliant documentation.
From a 3PL standpoint, handling both from the same inbound shipment is possible but requires clear workflow separation. The same inventory cannot go through a B2C pick-pack line and a B2B pallet-staging line simultaneously.
If you are scaling a brand across direct-to-consumer and wholesale channels simultaneously, confirm with your 3PL that both workflows are available and that lead times for each are clearly defined.